MDK-7526 cas 1448297-52-6

Product Name: MDK-7526 cas 1448297-52-6 CAS: 1448297-52-6 MF: C22H30N4O3S MW: 430.56 Mol File: 1448297-52-6.mol

Product Description

Product Name: MDK-7526 cas 1448297-52-6

Synonyms: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;3-Methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide;PROTAC-VHL-ligand;(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrro;CPD1584;MDK-7526;(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide HCl

CAS: 1448297-52-6

MF: C22H30N4O3S

MW: 430.56

Mol File: 1448297-52-6.mol

The specification of MDK-7526 cas 1448297-52-6

Inspection items	Standard	Results
Appearance	Off-white to Light yellow power	Conforms
(IR)	Should be conform to the structure	Conforms
NMR Determination	Should be conform to the structure	Complies
Loss On Drying	0.5%（0.5% Max）	0.16%
(HPLC Purity at 210 nm)：	98%（98% Min）	99.54%
Conclusion	The result confirm the enterprise standard

The usage of MDK-7526 cas 1448297-52-6

MDK-7526 cas 1448297-52-6 acts as a reagent in the synthesis of PROTAC compounds that mediated the degration of oncogenic c-ABL and BCR-ABL.

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.

MDK-7526 cas 1448297-52-6