MDK-7526 HCL cas 1448189-80-7

Product Name:MDK-7526 (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Synonyms: CAS: 1448189-80-7 MF: C22H31ClN4O3S MW: 467.03 EINECS: 604-604-1 Product Categories: Mol File: 1448189-80-7.mol

Product Description

Product Name:MDK-7526 HCL cas 1448189-80-7

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

Synonyms: (S,R,S)-AHPC hydrochloride;MDK-7526;ULM-1;(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide hydrochloride;Protein degrader 1;141003;(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride;CS-2718;Degradation Inducing Moiety A

CAS: 1448189-80-7

MF: C22H31ClN4O3S

MW: 467.03

EINECS: 604-604-1

Product Categories:

Mol File: 1448189-80-7.mol

The specification of MDK-7526 HCL cas 1448189-80-7

Inspection items	Standard	Results
Appearance	Off-white to Light yellow power	Conforms
(IR)	Should be conform to the structure	Conforms
NMR Determination	Should be conform to the structure	Complies
Loss On Drying	0.5%（0.5% Max）	0.16%
(HPLC Purity at 210 nm)：	98%（98% Min）	99.54%
Conclusion	The result confirm the enterprise standard

The usage of MDK-7526 HCL cas 1448189-80-7

2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Hydrochloride acts as a reagent in the synthesis of PROTAC compounds that mediated the degration of oncogenic c-ABL and BCR-ABL.

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.

MDK-7526 cas 1448189-80-7