Praziquantel CAS#55268-74-1

Praziquantel (), also known as Biltricide or Droncit, is a medication primarily used to treat parasitic infections like schistosomiasis and tapeworm infections in humans and animals, respectively. It was first synthesized in 1972 and approved for medical use in the United States in 1982.

Description: is a synthetic isoquinoline-pyrazine derivative that is effective against various species of parasitic worms. It works by disrupting the parasite's surface membrane, causing damage to it, and ultimately resulting in its death. Praziquantel is primarily active against adult parasites and has no significant effect on the eggs, larvae, or juveniles.

Synonyms: Praziquantel is also known by various other names, including 2-Cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, Dihydrochloride salt, and Praziquantelum.

Appearance: Praziquantel is a white to almost white, crystalline powder with a bitter taste.

Molecular formula: C19H24N2O2

Praziquantel Chemical Structure:

Solubility: Praziquantel is slightly soluble in water, soluble in methanol, and practically insoluble in acetone, ether, and chloroform.

Melting point: The melting point of Praziquantel is in the range of 136 - 140°C.

Density: The density of Praziquantel is about 1.2 g/cm3.

Characteristics: Praziquantel is safe and well-tolerated when used as directed, with only minor side effects reported in some people. Common side effects may include nausea, vomiting, abdominal pain, and headache. Serious side effects like allergic reactions, seizures, or liver and kidney problems are rare but possible and require immediate medical attention.

Applications: Praziquantel is widely used in the treatment of numerous parasitic infections, including schistosomiasis, liver fluke infections, and tapeworm infections in humans and animals. It is also used in the laboratory as a research tool to study the effects of parasites on the host organism.

Praziquantel anti-worm effect: broad-spectrum anti-fluke and tapeworm drug, suitable for various schistosomiasis, clonorchiasis, paragonimiasis, fascioliasis, tapeworm and cysticercosis.

Mechanism of action of praziquantel: After oral administration of drugs containing praziquantel, it can directly cause the muscles of parasites to contract forcibly, and can also damage the cortex of parasites, which can play a role in repelling parasites. In addition to the deworming effect through the above two methods, the drug can also inhibit the synthesis of parasite nucleic acid and protein.

Package & transportation: The quality standard of praziquantel meets the latest version of EP/USP/CVP, and the packaging specification is 25kg/barrel, or . It should be stored in a cool, dry place, away from direct sunlight and moisture. It is recommended to transport Praziquantel in dry, clean, and secure containers that prevent contamination and accidental spills.

Manufacture Procedures: Praziquantel is produced through a multi-step synthesis process, starting from the reaction of 2-aminopyrazine with cyclohexanone. The process involves several steps of chemical transformations, including acylation, cyclization, and reduction, among others. All production processes adhere to stringent global standards, aligning with the current versions of USP, EP, and CVP. This ensures optimum product quality and integrity. The safety, efficiency, and broad spectrum of Praziquantel API make it an excellent choice for diverse demographic users.

Conclusion: CAS#55268-74-1, praziquantel is a dual-use API for humans and animals, widely used in humans, animals, poultry, and pets for anti-parasitic treatment. In recent years, it has been found that praziquantel has a good effect on the treatment of parasitic diseases in freshwater fish. Praziquantel is a potent and effective antiparasitic drug that has helped save countless lives throughout the world. Its safety, reliability, and ease of use make it an essential tool in the fight against parasitic infections. However, like all medications, it should be used responsibly and under the guidance of a medical professional to ensure its safety and effectiveness.